acute necrotizing encephalopathy of childhood; a case report

how to cite this article: salehi omran mr, nooreddini h, baghdadi f. acute necrotizing encephalopathy of childhood; a case report. iran j child neurol. 2013 spring;7(2):51-54.   abstract acute necrotizing encephalopathy of childhood (anec) is an atypical disease followed by respiratory or gastrointestinal infection, high fever, which is accompanied with rapid alteration of consciousness and seizures. this disease is seen nearly exclusively in east asian infants and children who had previously a good health. serial mri examinations demonstrated symmetric lesions involving the thalami, brainstem, cerebellum, and white matter. this disease has a poor prognosis, often culminating in profound morbidity and mortality. a 22-month infant with anec hospitalized in amirkola children hospital has been evaluated. references 1. mizuguchi m. acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in japan and taiwan. brain dev. 1997 mar;19(2):81-92. review. 2. wang hs, huang sc. acute necrotizing encephalopathy of childhood. chang gung med j 2001 jan;24(1):1-10. 3. campistol j, gassió r, pineda m, fernandez-alvarez e. acute necrotizing encephalopathy of childhood (infantile bilateral  thalamic necrosis): two non-japanese cases. dev med child neurol 1998 nov;40(11):771-4. 4. ito y, ichiyama t, kimura h, shibata m, ishiwada n, kuroki h, furukawa s, morishima t. detection of influenza virus rna by reverse transcription-pcr and proinflammatory cytokines in influenza-virus-associated encephalopathy. j med virol 1999 aug;58(4):420-5. 5. sugaya n. influenza-associated encephalopathy in japan. semin pediatr infect dis 2002 apr;13(2):79-84. review. 6. skelton bw, hollingshead mc, sledd at, phillips cd, castillo m. acute necrotizing encephalopathy of childhood: typical findings in an atypical disease. pediatr radiol 2008 jul; 38(7):810-3. 7. wong am, simon em, zimmerman ra, wang hs, toh ch, ng sh. acute necrotizing encephalopathy of childhood: correlation of mr findings and clinical outcome. ajnr am j neuroradiol 2006 oct; 27(9): 1919-23. 8. mizuguchi m. [acute necrotizing encephalopathy of childhood]. ryoikibetsu shokogun shirizu 2000; (30 pt 5):527-30. review. japanese. 9. san millan b, teijeira s, penin c, garcia jl, navarro c. acute necrotizing encephalopathy of childhood: report of a spanish case. pediatr neurol 2007 dec; 37(6): 438- 41. 10. mizuguchi m, abe j, mikkaichi k, noma s, yoshida k, yamanaka t, et al. acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. j neurol neurosurg psychiatry 1995 may; 58(5): 555-61. 11. weng wc, peng ss, lee wt. acute necrotizing encephalopathy of childhood with spinal cord involvement: a case report. j child neurol 2010 dec; 25(12):1539-41. 12. ozawa t, nakashima y, ito r, hirano a, kondo t. eeg findings in a case of acute necrotizing encephalopathy of childhood associated with influenza a virus infection. no to hattatsu 2001 jan;33(1):63-8. japanese. 13. kurachi y, kawahara h, hatakeyama k, yazawa k, kubota m, oka a, et al. acute necrotizing encephalopathy with horizontal gaze palsy. no to shinkei 1997 aug;49(8): 753-8. japanese.